12-O-Methylcarnosic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

12-O-甲基鼠尾草酸是从小叶鼠尾草丙酮提取物中分离出来的二萜鼠尾草酸，是抑制 5α-还原酶的活性成分，IC50 值为 61.7 μM。12-O-甲基鼠尾草酸具有抗氧化活性，有效预防胃部病变。

12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM.12-O-Methylcarnosic acid has antioxidant activity, it is effective preventing gastric lesions.?12-O-Methylcarnosic acid can suppress melanin production with downregulation of tyrosinase expression in HMV-II melanoma cells.12-O-Methylcarnosic acid may have anti-diabetic activity, it is able to significantly activate peroxisome proliferator-activated receptor (PPAR)γ.

12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%. 12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL.

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Endocrinology/Hormones

Reductase

5-α reductase

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62201-71-2

346.46

C21H30O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (144.32 mM)

[H][C@@]12CCc3cc(C(C)C)c(OC)c(O)c3[C@]1(CCCC2(C)C)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years